Apoptosis in Polycystic Kidney Disease: From Pathogenesis to Treatment
نویسندگان
چکیده
Apoptosis plays an important role in many developmental processes and contributes to cell and tissue homeostasis. Induction of apoptosis can involve the "intrinsic pathway", which is activated by diverse stress signals, and the "extrinsic pathway", which is activated by proapoptotic receptor signals at the cell surface. Excessive or aberrant apoptosis is a crucial factor in many human disorders, including polycystic kidney disease (PKD). Renal cyst formation is caused by dysregulation of cell proliferation, involving diverse and poorly understood molecular mechanisms. Elevated apoptosis of tubular epithelial cells has been
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